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The presence of a virus in the CNS associated with the pro-inflammatory response leads to inflammation in the neuronal tissue, which is thought to be one of the relevant mechanisms causing neural alterations in COVID-19 patients (Kempuraj et al

This cascade of oxidative damage to proteins, lipids, and DNA highlights the interconnected pathways through which NO affects neural integrity ( 6.2.2 Excitotoxicity NO acts as a noncompetitive inhibitor of NMDAR, disrupting their regulatory role in synaptic plasticity, memory, and learning (Wu et al., 2021)