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Additionally, certain enzymes rely on thiol groups for their catalytic mechanisms, wherein the sulfhydryl moiety acts as a nucleophile or participates in substrate binding

W.J.H., Elders, P.J.M., Lips, P., Dhonukshe-Rutten, R.A.M., Van Schoor, N.M., and De Groot, L.C.P.G.M

Abstract Glutathione is a tripeptide that plays a pivotal role in critical physiological processes resulting in effects relevant to diverse disease pathophysiology such as maintenance of redox balance, reduction of oxidative stress, enhancement of metabolic detoxification, and regulation of immune system function

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The effect of CHAC1 overexpression on cellular susceptibility to chemotherapy highlights its potential as a drug target