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A rational policymaker would complement smoking-cessation and- prevention programs with a tobacco harm-reduction strategy, ensuring that nicotine users experience the least possible harm consistent with their own risk preferences

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TP53 mutated NSCLC patients have shown benefit from immunotherapy and while never smoker patients have been shown to have poor response to immunotherapy [94], further studies of patients with co-mutations are needed to evaluate whether there is a role for immunotherapy either alone or in combination with chemotherapy and/or targeted therapy for this subgroup

Another key point is that real-world use is different from lab testing

Iain&Shani #6 Calikev said: Iain not sure if this helps