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10.1002/anie.201208390 Angewandte Chemie 112 TousifS.SinghD

In addition, a major problem in the treatment of NDs is the limited delivery of many medicinal products to the brain due to the presence of the bloodbrain barrier (BBB), which makes it difficult to reach sufficient concentrations of active substances in the brain and decreases their bioavailability 13

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Tsai-Turton & Lauderer in their publication in the journal Endocrinology reported that evidence proves oxidative stress (inflammation) induces apoptosis (cell death) in preovulatory follicles and that the antiapoptotic (preventing cell death) effect of FSH is mediated in part by stimulation of follicular glutathione (GSH) and suppression of ROS production