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Physical Symptoms Of Spice Detox Gastrointestinal Cramping Gastrointestinal cramping is a physical spice withdrawal symptom because cholinergic contractions are no longer inhibited by 77% due to the downregulation of CB1 receptors in the enteric nervous system (ENS), leading to [3]: Hopkins & Gilchrist (2013) studied a 30-year-old who no longer experienced severe crampy abdominal pain with intractable nausea and vomiting within 14 days of abstaining from spice and taking ondansetron, after previously smoking every hour during active use [6]

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