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Later generations of devices have achieved improved nicotine delivery by using different product designs and power settings, innovative materials, and nicotine salts in e-cigarette formulations 3,21,22,24,25

Non-menthol and menthol cigarettes marketed in 20232024 served as controls

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A bidirectional association has been observed between smoking and several psychiatric disorders, such as bipolar disorder 36 , schizophrenia 43 and anxiety 44 in observational studies