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In fermentation, ripening, and heating and/or overheating, acrolein is formed during the Maillard reaction as a result of the conversion of amino acids and the oxidative deamination of polyamines

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In the GBD database, age-standardized mortality rate (ASDR) denotes the number of deaths per 100000 population across different age groups

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The toxic components in cigarette smoke have been considered the greatest contributor to serious diseases, and the underlying pathological mechanisms have been widely studied (Hoffmann et al., 2001