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Therefore, to fully understand the effects of these compounds, it is relevant the cell cultures selected for performing these assays, as well as the use of in vivo models that mimic the real-life situation of chronic e-cigarette vapers to clarify their impact on human health

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PLoS Comput Biol (2008) 4(1):e2.10.1371/journal.pcbi.0040002 51 SecciMEAuberAPanlilioLVRedhiGHThorndikeEBSchindlerCWet alAttenuating nicotine reinforcement and relapse by enhancing endogenous brain levels of kynurenic acid in rats and squirrel monkeys

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