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In the UK, e-liquids are regulated by the Tobacco and Related Products Regulations (TRPR) and the Medicines and Healthcare Products Regulatory Agency (MHRA) (4), as well as the EU's Tobacco Products Directive (TPD) which set high standards for safety and the preclusion of chemicals known to be harmful when inhaled, like diacetyl

while some animal studies have found weight decreases with e-cigarette exposure, these results have not been confirmed in other models, and the overall effect on body weight in humans remains uncertain

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