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Tabe Y, Jin L, Hatanaka Y, Miida T, Kornblau SM, Andreeff M , Konopleva M

The generation of ROS can be activated by endogenous factors, such as the mitochondrial electron transport chain (ETC), NADPH oxidases (NOX), lipoxygenases (LOX), cytochrome P450, and xanthine oxidase (XO), or by exogenous causes such as pollutants, chemicals/drugs, radiation and heavy metals (Moussa et al., 2019)

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Glandular pattern rarely involves more than 50% of the neoplasm