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And more intuitively, chronic cigarette smoke was also found to induce apoptosis in mouse testis,35 and the number of germ cell, Leydig cell and Sertoli cell reflected concurrent reductions.36 Xu et al .37 investigated 31 differentially expressed proteins extracted from the testes of mice exposed daily to cigarette smoke using matrix-assisted laser desorption/ionization time of flight mass spectrometric (MALDI-TOF-MS) analysis

National Research Council and others have pointed to a potential technological revenge effect