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14 Nicotine acetylcholine receptors are then activated by a conformational change that opens the internal pore, allowing sodium and calcium ions to enter, 15 leading to glutamate release through the calcium-calmodulin cascades (see Figure 1)

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Other nicotine/tobacco products 5.1 Nicotine pouches 5.2 Heated tobacco products 5.3 Shisha Appendices Appendix 1: Methodology and survey weighting Appendix 2: Sample sizes for figures Appendix 3: Comparison with other surveys (ONS, STS) Appendix 4: Regulatory summary Appendix 5: Definitions and survey questions References 1