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Free Radic Res Commun
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The crystal structure of the seleninic acid form of human pGPx also indicates that Gln79 and Trp153 are located within hydrogen bonding distance of the selenium atom (Figure 1)
SIRT1 can also regulate the function of PGC-1 in cells by regulating the acetylation and activity level of PGC-1, as well as regulation of downstream transcription factors such as nuclear receptor peroxisome proliferator-activated receptor (PPAR), estrogen-related receptor (ERR), nuclear respiratory factor (NRFs), and mitochondrial transcription factor A (Tfam), further affecting mitochondrial production and function [17, 18], and regulating the metabolism of glucose and lipids [19]
L-glutathione is a naturally occurring antioxidant produced in the liver, composed of the amino acids L-glutamic acid, L-cysteine, and L-glycine
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