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Especially because regulators may not be as familiar with NAM data, it is essential for the regulated community to provide scientific justification for using NAM data in lieu of vertebrate animal data in a regulatory filing

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A study observed that heavy smokers have higher circulating markers of lipid peroxidation (malondialdehyde) and impaired antioxidant system, envisaged by the changes in activity of glutathione peroxidase and glutathione reductase [70]