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Orexin neurons inhibit sleep to promote arousal

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through the pelvic neural pathways).

Even if someone tried to eat the leaves in their raw state, they would get sick or possibly even die from nicotine poisoning

Moreover, using the standardized 10-item Penn State E-cigarette Dependence Index is an added strength to our study, as it has been shown in a prior study that the dependence score calculated by the scale correlates strongly with nicotine concentration in e-liquids 14