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PCD has been widely implicated in COPD pathogenesis, and the involvement of autophagy, including mitophagy, has been reported in not only apoptosis but also programmed necrosis, necroptosis

Loneliness can be severely life-altering even life-threatening for those who experience it

Available from: Butler A, Lindson N, Contextualising an increase in the use of oral nicotine pouches, The Lancet Public Health, 11, e2-e3 Truth Initiative

After transfection, cells were exposed to WCSE (400 g/ml) for 24 h, and apoptosis was quantified by morphological analysis and flow cytometry

A spokeswoman for Imperial Tobacco denied the company was breaking the law before adding: "we are providing a fresher, premium product to consumers"