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Methods Study design This study was a randomised, single centre, non-blinded, eight-arm cross-over PK study registered in International Standard Randomised Controlled Trial Number (ISRCTN) database (ISRCTN: 55307091) and approved by the Wales Research Ethics Committee (REC reference: 18/WA/0353

doi: 10.1016/j.yfrne.2010.03.003 Plkki, M

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