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p53-pS15 combined with FOXO4 in the nucleus of senescent cells inhibits p53 into the cytoplasm to mediate apoptosis and halt the cell cycle 9,11
Aged muscle stem cells treated with NNMT inhibitors regain proliferative capacity and regenerative function, reversing cellular senescence that normally accumulates with age
But because glutathione helps recycle other antioxidants like vitamin C and vitamin E, it frees them up to be re-used to remove free radicals and decrease oxidative stress
