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First described back in the 1950s, acne erupts in about one in ten people within days or even hours of getting an injection of vitamin B12, which then disappears rapidly when injection treatment is discontinued. At the time, we had no idea what the mechanism might be, and the problem remained unsolved until just a few years ago when we finally figured it out: Vitamin B12 modulates the gene expression of the skin bacteria that cause acne
For instance, inflammation covers several levels of interactions of many mediators of the inflammatory response, systematized in the atlas of inflammation, where various bioactive molecules play a role and can be a pharmacological target for pharmacological intervention [331]
