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In large part, the industry self-regulated to prohibit the sale of products to under-18 year olds before a government ban

Modified Risk Tobacco Products The modified risk tobacco product (MRTP) pathway is outlined in the 2009 Family Smoking prevention and Tobacco Control Act [and] allows companies to submit applications for the FDA to evaluate whether a tobacco product may be sold or distributed for use to reduce harm or the risk of tobacco-related disease associated with commercially marketed tobacco products. The FDA maintains that the products authorized to be marketed with this claim are neither safe nor FDA-approved

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The proteomics portions of this research were performed in the Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by the U.S

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