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Given the difficulties that this can represent for the tobacco companies, some such as Philip Morris International have expressed interest in abandoning their operations within this country

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PA then diffuses back into the bacilli, where it accumulates and exerts multiple effects against Mtb, including inhibition of fatty acid synthase, disruption of membrane potential, and interference with energy production by interacting with ribosomal protein S1 to inhibit trans-translation (Zimhony et al., 2007