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difference: 6.8%, P = 0.17), but brain atrophy rates and cognitive decline showed no significant differences (Tzimopoulou et al., 2010)

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CD8 + cytotoxic T lymphocytes mediate direct thyrocyte lysis via perforin, granzymes, and proteoglycans, and are recruited and activated by autoreactive CD4 + T cells through IL-12 and IFN- signaling