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Arguably the most compelling biopsychological account of the action of psychedelic therapy takes inspiration from recent functional magnetic resonance imaging findings of decreased brain network modularity after Psilocybin Therapy for depression in two independent datasets and cohorts, where the decreases correlated with improved symptom severity in both samples (Daws et al., 2022)
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Qualitative (examining implementation) and quantitative methods (following a randomized controlled trial design) will be used in this hybrid effectiveness-implementation pilot design ( Figure 1 Further, we will use well-tested data collection methods, training, and supervision to ensure intervention fidelity and biochemical verification of smoking status
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