Whether it is smoked in the form of cigarettes, cigars, bidis, pipes, or consumed as smokeless tobacco products such as chewing tobacco, gutka, khaini, paan with tobacco, and snuff, tobacco significantly increases the risk of developing cancers of the mouth and surrounding tissues
Ontario Energy Board
And this is one of the better ones
In summary, data from both human and animal studies indicate that Th17 cell is actively involved in worsening smoking-associated inflammation and autoimmune diseases, including COPD, CD, colitis, RA and psoriasis, although nicotine can mitigate colitis in mice via suppression of IL-17 expression
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