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Medicines Your doctor might prescribe medicines including: Nitrates or calcium channel blockers to relax and widen blood vessels, letting more blood flow to your heart Beta-blockers to slow your heart down so it doesn't have to work as hard Blood thinners or antiplatelet medications to prevent blood clots Statins to lower your cholesterol levels and stabilize plaque Cardiac procedures If meds aren't enough, you may need to have a medical procedure or surgery to open blocked arteries