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By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

A deficiency in vitamin B12 results in an insufficiency of mature red blood cells containing haemoglobin, the oxygen carrying pigment that distributes oxygen to all the tissues around the body

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In this guide, we explain what these peptides are, what the science says so far, the risks you should know about, and what changed with the FDA in 2026