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Direct Toxic Effects of Cigarette Smoke on Intestinal Milieu/Autoimmunity While there is little doubt, as this review has already demonstrated, that smoking is detrimental to treatment outcomes in IBD based on a multitude of observational data, there are remarkably few studies that have explored the underlying mechanisms of which and how particular constituents of tobacco smoking affect the intestinal milieu and/or relevant immune-inflammatory pathways

Re-examining the doseresponse smoking association after controlling for potential mediating and confounding variables (Model 3) with an FDR threshold set at 0.05 revealed a strongly attenuated pattern of significant associations

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