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The functionalization usually provides with colloidal stability, allows for stearic or electrostatic binding with the active therapeutic drug, targeting moieties, or the imaging probe, and tuning important properties of pharmacokinetics, systemic toxicity, clearance, cellular interactions, and non-specific protein absorptions [5, 16, 123, 206,207,208,209,210,211,212,213,214,215]

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In the body, O 2 - anions are intended products of redox signaling enzyme cascade and byproducts of several metabolic processes including mitochondrial respiration 555

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