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If this mutation occurs in a critical region of an oncogene such as KRAS or a tumor suppressor gene such as TP53 , the result is undeniably loss of normal cellular growth control mechanisms and development of cancer

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[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Liu SV, Minasi LAE, Herpers M & Frohn C Efficacy of afatinib in patients with advanced/metastatic solid tumors harboring NRG1 gene fusions: a novel, prospective real-world outcomes study based on single-patient protocol data

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