Yes, glutathione occurs naturally in the body and is safe under medical supervision.
Its accumulation reflects impaired glutathione regeneration, loss of regulatory control within the -glutamyl cycle, and metabolic conditions that favour diversion of intermediates away from productive glutathione synthesis
In lipopolysaccharide (LPS)-induced depressive rat models, curcumin pre-treatment reduced neuronal death in the hippocampal CA1 region, likely via the miR-146a-5p/ERK signaling pathway, and was associated with improved synaptic function ( Patients with myocardial infarction (MI) exhibit significantly increased risks of developing depression and anxiety disorders (Sun et al., 2021
154, 491497 10.1083/jcb.200103047 [DOI] [PMC free article] [PubMed] [Google Scholar] Janzer R
Meanwhile, low levels of follicular glutathione are associated with premature ovarian aging and lower fertilization rates