smokeless tobacco health effects Snus: Facts and Risks What Nicotine Does to Your

FDA approves sale of reduced-nicotine cigarettes Giving up cigarettes is easier when they contain less nicotine, a chemical stimulant that's highly addictive

At several p53 mutational hotspots common to all cancers, such as codons 248 and 273, a large fraction of the mutations are G to T events in lung cancers but are almost exclusively G to A transitions in non-tobacco-related cancers

They attack organs such as the lungs, oesophagus and pancreas, where they impair the bodys own defences against cancer cells, which in turn increases the risk of developing cancer

Irritating, but

The primary enzyme metabolizing nicotine is CYP2A6, encoded by a highly polymorphic gene