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Potential mechanisms by which smoking increases respiratory infection risk include structural changes to the respiratory tract and a dysregulated cellular and humoral immune response, including peribronchiolar inflammation, decreased levels of circulating immunoglobulins, and changes to pathogen adherence

3 = severe

Before it became a subject of focused attention, it appeared in artworks showing it as part of daily life, with cups, plates, candlesticks, and tea services often depicted

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