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The emphasis then was on tough, scrappy rhythm guitar work, catchy chord progressions and tight, melodic songcraft as exemplified by the early recordings of the Beatles, Stones, Who and Kinks, not to mention the Easybeats, the hit-making Australian beat group led by Angus and Malcolms elder brother George

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Dysregulation of these pathways through chronic exposure to cigarette smoke or nicotine may therefore impair immune homeostasis and promote persistent inflammatory signaling, further contributing to immunosenescence-like patterns in people with MS

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