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Single-cell gene expression analysis from a publicly available database [18] suggested dysregulation of both GPX4 as well as iron handling in proximal tubular epithelial cells of the S3 segments, which are known to be the most ferroptosis-prone part of the nephron[24] (Fig

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The outcome was not a surprise after FDA briefing documents released on Monday took issue with NurOwns manufacturing plan and said the company failed to demonstrate substantial evidence of efficacy in its Biologics License Application