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UK: Oxford University Press, oxford university, 141148

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Furthermore, cigarette smoke leads to the accumulation of damaged and misfolded proteins in the endoplasmic reticulum (ER), a condition known as ER stress, accompanied by enhanced unfolded protein response (UPR)

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A 2025 review of nine studies involving more than 400,000 pregnant women found that, compared to not smoking, using e-cigarettes significantly increased the risk of preterm birth, low birth weight, and small-for-gestational-age babies, which may require hospitalization in the neonatal intensive care unit (NICU)