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The weight loss was consistent throughout the study period and showed a continued downward trend beyond week 36, suggesting a potential for sustained long-term activity

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Simultaneously, AOD-9604 inhibits lipogenesis by downregulating enzymes involved in converting excess calories into stored fat

RESULTS All of the NSAIDs induced both lower esophageal and pyloric sphincters pressure fall, and thereby the induced sphincter failure may be a common phenomenon of NSAIDs, with some particularities for the used non-specific (diclofenac, ibuprofen, aspirin, paracetamol) and specific (celecoxib) NSAIDs ( Figs