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Associated with progression is the development of an increased degree of karyotypic instability and of aneuploidy

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Smoking and the reduced life expectancy of individuals with serious mental illness

[5] [4] The long-term use of nicotinic acid at greater than or equal to 2 grams per day also significantly increases the risk of cerebral hemorrhage, ischemic stroke, gastrointestinal ulceration and bleeding, diabetes, dyspepsia, and diarrhea

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