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According to the FDA, however, this could soon change

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24 Alcohol consumption enhances the risk of AF in a fairly linear fashion, with clear evidence that binge drinking heightens the risk

Canadian authors of a 2020 meta-analysis of 32 RCTs of drug treatment for major depressive disorder in people with concurrent SUDs concluded that SSRIs either alone or in combination with relapse prevention medications such as naltrexone, had no significant effect on depressive symptoms