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A hepatitis B immune globulin (HBIg) approved by the FDA to both prevent hepatitis B virus (HBV) recurrence following liver transplantation in HBsAg-positive patients and provide post-exposure prophylaxis 1-3 Indications and Important Safety Information for HepaGam B Indications HepaGam B [Hepatitis B Immune Globulin Intravenous (Human)] is an intravenous immune globulin indicated for the following: Prevention of Hepatitis B recurrence following liver transplant in HBsAg-positive liver transplant patients Post-exposure prophylaxis including: Acute exposure to HBsAg-positive blood, plasma, or serum (parenteral exposure, direct mucus membrane contact, oral ingestion, etc.), Perinatal exposure of infants born to HBsAg-positive mothers, Sexual exposure to HBsAg-positive persons, and Household exposure to persons with acute HBV infection

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