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15 These results support the hypothesis that NAC is capable of crossing the bloodbrain barrier and providing cysteine substrate to CNS cells, thus enhancing GSH synthesis

Its phase 3 trial showing efficacy there, not where the primary outcome is the improvement of the complication

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doi:10.1016/S0022-2275(20)33379-4

In women with episodic migraines ( n = 92), ALA (300 mg twice daily) for 12 weeks significantly reduced migraine severity and frequency, and reduced serum lactate and vascular cell adhesion molecule-1, suggesting improvement in mitochondrial and endothelial function, respectively