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For general background on how investigational peptides are evaluated for safety, the National Institutes of Healths overview of how experimental compounds move through clinical evaluation illustrates why oversight matters at every stage

In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

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doi: 10.1096/fj.00-0584fje

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