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Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]

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The authors believe levels will continue to rise unless more steps are taken to reduce fossil fuel emissions and curb climate change