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Human embryonic stem cell-derived MSCs can also treat CTX-induced POF mice, potentially through paracrine mechanisms that involve the secretion of VEGF, IGF-2, and hepatocyte growth factor which help improve ovarian function, reduce granulosa cell apoptosis, and restore fertility [129]

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Natural killer (NK) cells are prevented from ingesting and destroying tumor cells, pathogens, and other foreign invaders in circulation(5)54

Reed MB, Strugnell RA, Panaccio M, Spithill TW: A novel member of the NK-lysin protein family is developmentally regulated and secreted by Fasciola hepatica

175 For the PPP enzymes, recent studies have discovered some inhibitors targeting on G6PD, such as NADP + analogs, the competitive inhibitor 6-aminonicotinamide (6-AN), noncompetitive inhibitors epiandrosterone and dehydroepiandrosterone (DHEA) which reduces the availability of NADPH and inhibits the cell growth