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Although cell models enable targeted investigation of lipid metabolism, peptide absorption, and signaling pathways, they lack the systemic complexity of living organisms, including organ interactions and metabolic pathways, and do not replicate in vivo digestive processes

Cox proportional hazards regression analyses were used to assess the effect of clinical variables on patient survival

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Phase II metabolism, also known as conjugation or synthetic metabolism, is the second phase of drug and xenobiotic metabolism that follows Phase I metabolism

This VDF cocktail induced high expression of key hepatic markers such as AFP, HNF4, and Albumin (ALB), with an efficiency of 95.5% (HNF4a+/AFP+ positive cells), closely matching that of the growth factor-based control