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Here, we use single-cell RNA-sequencing (scRNA-seq) to define the transcriptional cell types and states of the tracheal airway epithelium in smokers and non-smokers, infer the lineage relationships among these cells, and determine the influence of cigarette smoke on individual surface and SMG airway epithelial cell types with single-cell resolution

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Eur Respir J 13(6):12601266