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however, we had concerns regarding the extremely wide CI and generalizability of the study design to practice.36 Another RCT ( n = 624) examined non-nicotine e-cigarettes with behavioural support and nicotine patch access versus behavioural support and nicotine patch access alone.28 Non-nicotine e-cigarette use may result in a small cessation benefit (16 more per 1000, 95% CI 12 fewer to 109 more

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Over time, repeated exposure to nicotine leads to changes in the brains chemistry, resulting in tolerance, dependence, and withdrawal symptoms when tobacco use is discontinued