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But if you spread those 200 puffs out over 16 hours, your blood nicotine levels might remain lower and more stable than if you smoked 10 cigarettes in spikes throughout the day

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Namely, there is a significantly increased risk of sudden infant death syndrome 2,14 , obesity 2,14 , type 2 diabetes 2,14,17 , earlier menarche for girls 2 , and reduction in male reproduction ability 19 , respiratory effects (upper respiratory tract infections, bronchitis and other lower respiratory tract infections, pulmonary hypertension, compromised lung function, increased rate of lower respiratory tract infections, impaired lung function, wheezing and asthma 2,14 , cardiovascular effects (hypertension) 2,14 , neurologic effects (developmental abnormalities in the brain, decreased brain measurements, impairments in normal brain activity) 2 , neurodevelopmental and behavioral effects 2,14 (abnormal behavioral and neurodevelopmental outcomes) 2 , global intelligence/ academic performance 2 , Attention Deficit/ Hyperactivity Disorder (ADHD) 2,20 , externalizing behaviors 2,20 , antisocial behavior, nicotine dependence 14 and future substance abuse 2 , significant increase risk for early psychiatric disorders 21 in early adulthood, and necrotizing enterocolitis (NEC) 2

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