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When incubated with brain endothelial cells, cotinine and nicotine decrease ZO-1 expression ( Moreover, the comparative effect of TS and e-cig extract showed that downregulation of ZO-1 protein from e-cig was not dissimilar to that from TS extract treatment (Kaisar et al., 2017)

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Transport phenomena governing nicotine emissions from electronic cigarettes: Model formulation and experimental investigation