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As for the enzymatic process, nicotine is converted into cotinine, which is the main metabolite, ensuring that around 7080% of nicotines filtration is done through the liver

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However, Italy has shown steady growth in the adoption of electronic nicotine delivery systems (ENDS), driven by urban consumers seeking harm-reduction alternatives

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Cases like that of Ashraf Youssef, who received jail time and probation for evading over $467,000 in excise taxes on illegal e-cigarette sales, highlight the severity