[Google Scholar] Archana E, Pai P, Prabhu BK, Shenoy RP, Prabhu K, Rao A
Heat and Temperature Fluctuations Impact : Critical Primary damage: Hydrolysis Denaturation Deamidation Damage begins within hours if storage temperatures remain elevated
Delivery of copper using BBB permeable delivery agents such as diacetyl-bis (N4-methylthiosemicarbazone) (CuATSM) used to restore copper deficiency in ALS (Hilton et al., 2024), or administration of the endogenously produced neurotrophic copper binding tripeptide Glycyl-L-Histidyl-L-Lysine -copper (GHK-Cu) (Pickart et al., 2017), or else adding PBT2-Cu would be of interest for investigation
PINK1 primes Parkin-Mediated ubiquitination of PARIS in dopaminergic neuronal survival
Recent studies, however, have mixed results